Soderholm’s research has focused on rare-earth and actinide science since her early work on electronic and magnetic properties of their solid-state oxides, including the newly discovered high-temperature superconductors. Through her research, she has also sought to understand f-ion speciation in solution, taking advantage of X-ray probes at Argonne’s Advanced Photon Source to link molecular correlations in solution to bulk thermodynamic properties. Her recent efforts center on the use of machine learning to study molecular structures in connection with low-energy processes for separation of f-block elements from complex mixtures.