Leonard Favreau

Dept Pharmacokinet Pharmacodynam & Drug Metab Merck & Co Inc

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论文共 22 篇作者统计合作学者相似作者

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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Mihirbaran Mandal,Kaushik Mitra,Diane Grotz,Xinjie Lin,Jairam Palamanda,Pramila Kumari,Alexei Buevich,John P. Caldwell,Xia Chen,Kathleen Cox,Leonard Favreau,Lynn Hyde,Matthew E. Kennedy,Reshma Kuvelkar, Xiaoxian Liu,Robert D. Mazzola,Eric Parker,Diane Rindgen,Edward Sherer,Hongwu Wang,Zhaoning Zhu,Andrew W. Stamford,Jared N. Cumming

Journal of Medicinal Chemistry（2018）

引用11浏览0WOS引用

非人類霊長類での中央部Aβを低減するイミノ複素環系β‐位アミロイド前駆体蛋白質切断酵素(BACE)阻害剤の構造ベース設計

Mandal Mihirbaran,Yusheng Wu,M Schkeryantz Jeffrey,Li Guoqing,Buevich Alexei,P Caldwell John,Xiaoxiang Liu,D Mazzola Robert,Peter Orth,Strickland Corey,Voigt Johannes,Hongwu Wang,Zhaoning Zhu,Xia Chen,Grzelak Michael,A Hyde Lynn,Reshma Kuvelkar,T Leach Prescott,Giuseppe Terracina,Lili Zhang,Zhang Qi,Scherer Maria,Smith Brad,Cox Kathleen,Grotz Diane,Favreau Leonard,Mitra Kaushik,Irina Kazakevich,A Mckittrick Brian,Greenlee William,E Kennedy Matthew,M Parker Eric,N Cumming Jared,W Stamford Andrew

Journal of Medicinal Chemistryno. 7 (2016): 3248

引用0浏览0引用

Structure-Based Design of an Iminoheterocyclic Β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor That Lowers Central Aβ in Nonhuman Primates

Mihirbaran Mandal,Yusheng Wu,Jeffrey Misiaszek,Guoqing Li,Alexei Buevich,John P. Caldwell,Xiaoxiang Liu,Robert D. Mazzola,Peter Orth,Corey Strickland,Johannes Voigt,Hongwu Wang,Zhaoning Zhu,Xia Chen,Michael Grzelak,Lynn A. Hyde,Reshma Kuvelkar,Prescott T. Leach,Giuseppe Terracina,Lili Zhang,Qi Zhang,Maria S. Michener,Brad Smith,Kathleen Cox,Diane Grotz,Leonard Favreau,Kaushik Mitra,Irina Kazakevich,Brian A. McKittrick,William Greenlee,Matthew E. Kennedy,Eric M. Parker,Jared N. Cumming,Andrew W. Stamford

Journal of Medicinal Chemistry（2016）

引用38浏览0WOS引用

Structure Based Design of Iminohydantoin BACE1 Inhibitors: Identification of an Orally Available, Centrally Active BACE1 Inhibitor

Jared N. Cumming,Elizabeth M. Smith,Lingyan Wang,Jeffrey Misiaszek,James Durkin,Jianping Pan,Ulrich Iserloh,Yusheng Wu,Zhaoning Zhu,Corey Strickland,Johannes Voigt,Xia Chen,Matthew E. Kennedy,Reshma Kuvelkar,Lynn A. Hyde,Kathleen Cox,Leonard Favreau, Michael F. Czarniecki,William J. Greenlee,Brian A. McKittrick,Eric M. Parker,Andrew W. Stamford

ChemInform（2012）

引用134浏览0WOS引用

134

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Mihirbaran Mandal,Zhaoning Zhu,Jared N. Cumming,Xiaoxiang Liu,Corey Strickland,Robert D. Mazzola,John P. Caldwell,Prescott Leach,Michael Grzelak,Lynn Hyde,Qi Zhang,Giuseppe Terracina,Lili Zhang,Xia Chen,Reshma Kuvelkar,Matthew E. Kennedy,Leonard Favreau,Kathleen Cox,Peter Orth,Alexei Buevich,Johannes Voig,Hongwu Wang,Irina Kazakevich,Brian A. McKittrick,William Greenlee,Eric M. Parker,Andrew W. Stamford

Journal of Medicinal Chemistry（2012）

引用60浏览0WOS引用

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Andrew W. Stamford,Jack D. Scott,Sarah W. Li,Suresh Babu,Dawit Tadesse, Rachael Hunter,Yusheng Wu,Jeffrey Misiaszek,Jared N. Cumming,Eric J. Gilbert,Chunli Huang,Brian A. McKittrick,Liwu Hong,Tao Guo,Zhaoning Zhu,Corey Strickland,Peter Orth,Johannes H. Voigt,Matthew E. Kennedy,Xia Chen,Reshma Kuvelkar,Robert Hodgson,Lynn A. Hyde,Kathleen Cox,Leonard Favreau,Eric M. Parker,William J. Greenlee

ACS MEDICINAL CHEMISTRY LETTERS（2012）

引用104浏览0WOS引用

104

Novel Iminopyrimidinone Beta-Secretase (Bace) Inhibitors: P1-Thiophenes

Jack D. Scott,Sarah W. Li,Eric J. Gilbert,Chunli Huang,Jared Cumming,Ulrich Iserloh,Robert D. Mazzola,Suresh Babu,John Caldwell,Xia Chen,Kathleen Cox,Michael Czarniecki,James Durkin,Leonard Favreau,Tao Gu,William J. Greenlee,Robert Hodgson,Ying Huang,Lynn Hyde,Qin Jiang,Matthew Kennedy,Reshma Kuvelkar,Prescott Leach,Guoqing Li,Vincent Madison,Brian Mckittrick,Michael Miller,Peter Orth,Jianping Pan,Eric Parker, Paolo Pasetto,Andrew W. Stamford, Corey Stickland,Zhong-Yue Sun,Dawit Tadesse,Johannes Voigt,Lingyan Wang,Bonnie Werner,Jesse Wong,Yusheng Wu,Lili Zhang,Qi Zhang,Zhaoning Zhu

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2011）

引用0浏览0引用

Piperazine Sulfonamide BACE1 Inhibitors: Design, Synthesis, and in Vivo Characterization

Jared Cumming,Suresh Babu,Ying Huang,Carolyn Carrol,Xia Chen,Leonard Favreau,William Greenlee,Tao Guo,Matthew Kennedy,Reshma Kuvelkar,Thuy Le,Guoqing Li,Nansie McHugh,Peter Orth,Lynne Ozgur,Eric Parker,Kurt Saionz,Andrew Stamford,Corey Strickland,Dawit Tadesse,Johannes Voigt,Lili Zhang,Qi Zhang

Bioorganic & Medicinal Chemistry Letters（2010）

引用54浏览0WOS引用

Design And Synthesis Of Novel B-Secretase (Bace) Inhibitors

Robert D. Mazzola,Suresh Babu,John Caldwell,Xia Chen,Jared Cumming,Michael Czarniecki,Jinqi Duo,James Durkin,William J. Greenlee,Helen Gu,Tao Guo,Rachel Hunter,Ulrich Iserloh,Matthew E. Kennedy,Jianshe Kong,Reshma Kuvelkar,Lynn Hyde,Prescott Leach,Vincent Madison,Brian A. Mckittrick,Thuy Le,Tao Meng, Jeffery Misiaszek,Jianping Pan,Eric Parker,Gang Qian,Kurt Saionz,Andrew Stamford,Corey Strickland,Dawit Tadesse,Johannes Voigt,Lingyang Wang,Jesse Wong,Yusheng Wu,Jianhong Zhao,Zhaoning Zhu,Guoqing Li,Ying Huang,Yuanzan Ye,Kathleen Cox,Leonard Favreau,Daniel Wyss,Yu-Sen Wang,Zhong-Yue Sun

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2010）

引用0浏览0引用

The Synthesis and Structure-Activity Relationship of 4-Benzimidazolyl-piperidinylcarbonyl-piperidine Analogs As Histamine H-3 Antagonists

Pauline C. Ting,Joe F. Lee,Margaret M. Albanese,Jie Wu,Robert Aslanian,Leonard Favreau,Cymbelene Nardo,Walter A. Korfmacher,Robert E. West,Shirley M. Williams,John C. Anthes,Maria A. Rivelli,Michel R. Corboz,John A. Hey

Bioorganic & Medicinal Chemistry Letters（2010）

引用9浏览0WOS引用

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作者统计

#Papers: 22

#Citation: 787

H-Index: 13

G-Index: 16

Sociability: 5

Diversity: 2

Activity: 0

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