Lin Lin

1. Generation of genetically modified pigs for human diseases using CRISPR-Cas9 technology. 2. Methodological improvement and innovation in precise genome and epigenome engineering. 3. Targeted gene modification in neural stem cells using Transcription Activator-like Effector Nucleases (TALENs) and CRISPR-Cas9. 4. Generation of neural stem cell models for neurodegenerative disorders. 5. Stem cell biology, proliferation and differentiation. 6. The effects of environmental stress on developmental competence and cryotolerance on porcine embryos. 7. Optimization of cryopreservation of oocytes/embryos. 8. Optimization of somatic cell nuclear transfer of domestic animals including pig, sheep and cattle.