Dr. Wang’s Lab has several key areas of focus: 1) Transition from premalignant lesions to invasive cancer: The lab comprehensively characterizes the cellular and molecular trajectories of tumor development and progression, aiming to develop classifiers and risk prediction models for better patient stratification and to identify potential targets for developing effective interception strategies. 2) Evolution of metastasis from a localized tumor: The lab explores the cellular and molecular underpinnings of metastases, seeking to understand the co-evolution of cancer cells with the TME, and the adaptive interactions between cancer cells and various immune and stromal cells within both primary and metastatic microenvironments. 3) Dynamic response to anti-cancer therapies and the development of therapeutic resistance: The lab aims to pinpoint both intrinsic factors in cancer cells and the microenvironmental factors that determine tumor responses to anti-cancer therapies, identify robust biomarkers and develop models to predict patient response prior to treatment, and discover new targets for developing effective combination therapies.