Lisbeth A. Guethlein spends much of her time researching Genetics, Haplotype, Human leukocyte antigen, Immunology and KIR Ligand. Her Haplotype study is concerned with Allele in general. Her Human leukocyte antigen study frequently draws parallels with other fields, such as Receptor.

Her Receptor research is multidisciplinary, incorporating perspectives in Natural killer T cell, Epitope, Major histocompatibility complex and Lymphocyte. Her Immunology course of study focuses on Transplantation and Leukemia. Her KIR Ligand research focuses on subjects like KIR3DL1, which are linked to Molecular biology and Gene polymorphism.