Luka Č. Popović has been engaged in scientific research since 1990 (over 30 years), as well as accompanying but no less important work in the education of young researchers and the popularization of astronomy and science in general.

The scientific field in which he works is astrophysics, and specifical fields are: spectroscopy of laboratory and stellar plasma, active galactic nuclei, gravitational lenses, gamma rays; and research of the Earth's ionosphere.