His clinical interest is in acute coronary syndromes and critical care, and he attends in the Cardiac Intensive Care Units at both BWH and MGH. His research interests include coronary artery disease, acute coronary syndromes, dyslipidemias, proteomics and genomics. As the chairman of the TIMI Study Group—an academic research organization that has led major cardiovascular medicine clinical trials since its inception in 1984—Dr. Sabatine leads large-scale international randomized controlled trials testing novel therapies for cardiovascular care that have shaped the practice of medicine.

Dr. Sabatine has authored over 200 peer-reviewed publications, is on the writing committees for practice guidelines, and has received research funding from the American College of Cardiology and the National Institutes of Health.