Martin Falk

Assoc. Prof., RNDr. Martin Falk, PhD. Born on 14th May 1976 in Teplice, Czech Republic Institute of Biophysics of the Czech Academy of Sciences, v.v.i. Královopolská 135, 612 65 Brno, Czech Republic Head, Department of Cell Biology and Radiobiology Head, Laboratory of Chromatin Function, Damage and Repair Scientific Profile: Radiobiology, DNA double-strand break induction, repair and misrepair; mechanism of formation of chromosomal translocations, higher-order chromatin structure, function and dynamics in regulation of nuclear processes; carcinogenesis; leukemia; low/high-LET radiation risks and complex cellular response; tumor cell radiosensitization for radiotherapy; ion-beam cancer therapy, biological effects of different kinds of ionizing radiation; (live) cell imaging and image analysis, cell micro-irradiation INVOLVEMENT ●2022 – 2024 Hosting Professor, Heidelberg University, Heidelberg, Germany (one of the three best universities in Germany, 42nd position according to World University Rankings 2022) ●2021: Winner of the world competition to organize the International Congress on Radiation Research in 2027 (ICRR2027; the largest radiobiological conference with hundreds to thousands of participants) ●Council Member of the European Radiation Research Society (ERRS) ●President of Radiobiological Society for Crisis Planning of the Czech Medical Society of JE Purkyně ●Academic Assembly of the Czech Academy of Sciences (voted member) ●Expert of the Czech Academy of Sciences for Radiobiology ●Czech Republic Management Committee Member in EU-COST projects: RADAM (MP1002 CZ), Nano-IBCT (MP1002 CZ), CliniMARK (CA16113), MultiChem (CA20129) AWARDS ● 2021: A Prize of the European Radiation Research Society (ERRS) awarded to I Falkova et al., 46th Annual Meeting of the ERRS (ERRS 2021), November 26th – 30, 2021, Caen, France. ●2018: 1st Prize, The Society for Low Temperature Biology (SLTB) Meeting, 6th Sept 2018, Prague, CR (Falk M. et al. Complex description of cryopreserved cell nuclei defects by immunofluorescence microscopy: DNA lesions, chromatin decondensation, nuclear membrane ruptures; presented by M Golan). ●2015: Young Investigators Travel Award, 15th International Congress of Radiation Research (ICRR 2015), Kyoto, Japan. ●2009: Premium of Otto Wichterle for outstanding young scientists, Award of the Czech Academy of Sciences ●2008: The Prize of Deutsche Gesellchaft für DNA-Reparaturforschung (DGDR), 10th Biennial Meeting of the DGDR, Berlin, Germany: Devoted for results obtained at the field of DNA repair: “Different sensitivity and response of functionally distinct chromatin domains to DSB induction” ● 2008: Second place, New England Biolabs Poster Prize, Biochemical Society Annual Symposium – DNA Damage: From Causes to Cures, December 15-17, 2008, Cambridge, Great Britain, ● 2004: The Prize of Institute of Biophysics of ASCR for excellent young scientists ● >30 invited lectures until now SELECTED PUBLICATIONS ●Falk, M., et al. Chromatin structure influences the sensitivity of DNA to γ-radiation. BBA MCR, 2008, 1783(12), 2398-2414. IF 6.090 (Q1 at the publishing date), cited 139 times ●Falk, M. et al. Higher-order chromatin structure in DSB induction, repair and misrepair. MutationResearch - Reviews in Mutation Research, 2010, 704(1-3), 88-100. IF 8.741 (Q1), cited 104 times ●Falk, M. et al. Chromatin dynamics during DSB repair. BBA MCR, 2007, 1773(10), 1534-1545. IF 6.090 (Q1 at the publishing date), cited 101 times ●Kozubek S. et al. 2002. 3D Structure of the Human Genome: Order in Randomness, Chromosoma 111/5: 321-331 (IF=3.442, Q1), cited 98 times. ●Dobešová L, et al., and Hausmann M (corresp. au.). Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells. Pharmaceutics 2022, 14(1), 166; IF 6.525 (Q1). ●Vicar T, at al. DeepFoci: Deep learning-based algorithm for fast automatic analysis of DNA double-strand break ionizing radiation-induced foci. Comput Struct Biotechnol J. 2021;19:6465-6480. eCollection 2021. IF 7.271 (Q1). ●Jezkova, L., et al. Particles with similar LET values generate DNA breaks of different complexity and reparability: A high-resolution microscopy analysis of γh2AX/53BP1 foci. Nanoscale, 2018, 10 (3), 1162-1179. IF 8.307 (Q1), cited 41 times ●Stefancikova L et al. Effect of Gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells. J Nanobiotechnol. 2016;14(1):63. IF= 10.435 (Q1) cited 43 times ●Hofer M. et al. Two new faces of amifostine: protector from DNA damage in normal cells and inhibitor of DNA repair in cancer cells. Journal of Medicinal Chemistry, 2016, 59(7), 3003-3017. IF = 8.039 (Q1), cited 47 times ●Falk M et al. Chromatin architecture changes and DNA replication fork collapse are critical features in cryopreserved cells that are differentially controlled by cryoprotectants. Scientific Reports (Nature) 2018, 8(1), 14694. IF= 4.996 (Q1), cited 24 time