Since 1990 Dr Salvetti is involved in research activity on: -The pathophysiology of target organ damage (cardiac hypertrophy, atherosclerosis, arterial stiffening, small arteries structural and functional changes, renal damage) in essential hypertension -The interrelationships between cardiac and vascular changes and their regression after treatment in essential hypertension. - The noninvasive evaluation of endothelial function - The noninvasive evaluation of arterial atherosclerosis - The noninvasive evaluation of arterial stiffness - Clinical pharmacology and therapeutic use of CV drugs, mainly antihypertensive and antianginal agents. -The role of the sympathetic nervous system and of the renin-angiotensin-aldosterone system in the pathogenesis of essential hypertension, angina pectoris and HF -The application of computerized analysis of ECG and BP recording in the evaluation of CHD and in hypertension .