Matt Simon

基本信息

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职业迁徙

个人简介

Research Summary
My laboratory develops chemical and biochemical tools to study regulated gene expression with a focus on chromatin and RNA biology.

Specialized Terms: Chemical biology; Epigenetic regulation; Histone modifications; RNA metabolism

研究兴趣

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Rapid Folding of Nascent RNA Regulates Eukaryotic RNA Biogenesis

Leonard Schärfen,Isaac W Vock,Matthew D Simon,Karla M Neugebauer

Molecular cellno. 8 (2025): 1561-1574.e5

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RBM15-MKL1 Fusion Protein Promotes Leukemia Via M6a Methylation and WNT Pathway Activation

Madeline Y Mayday,Giulia Biancon, Manyi Wei, Christian Ramirez,Irene Moratti, Andreas P Pintado-Urbanc, Jether Amos Espinosa, Mi Chen,Lin Wang,Matthew D Simon,Yaara Ofir-Rosenfeld,Oliver Rausch,Toma Tebaldi,Stephanie Halene,Diane S Krause

Blood (2025)

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Transcription Elongation Factor ELOF1 is Required for Efficient Somatic Hypermutation and Class Switch Recombination

Lizhen Wu,Anurupa Devi Yadavalli, Filip Senigl,Gabriel Matos-Rodrigues,Dijin Xu,Andreas P Pintado-Urbanc,Matthew D Simon,Wei Wu,André Nussenzweig,David G Schatz

Molecular cellno. 7 (2025): 1296-1310.e7

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Fc-engineered Large Molecules Targeting Blood-Brain Barrier Transferrin Receptor and CD98hc Have Distinct Central Nervous System and Peripheral Biodistribution

Nathalie Khoury,Michelle E Pizzo, Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha, Gabrielly L De Melo, Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow, Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker, Holly Kane,Amy Leung, Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk, Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Nature communicationsno. 1 (2025): 1822-1822

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Uncovering the Isoform-Resolution Kinetic Landscape of Nonsense-Mediated Mrna Decay with EZbakR

Justin W Mabin, Isaac W Vock,Martin Machyna,Nazmul Haque, Poonam Thakran, Alexandra Zhang,Ganesha Rai, Isabelle Nathalie-Marie Leibler,James Inglese,Matthew D Simon,J Robert Hogg

bioRxiv the preprint server for biology (2025)

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Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Scarlett J. Barker,Mai B. Thayer,Chaeyoung Kim,David Tatarakis,Matthew J. Simon, Rebekah Dial, Lizanne Nilewski,Robert C. Wells,Yinhan Zhou,Megan Afetian,Padma Akkapeddi,Alfred Chappell,Kylie S. Chew,Johann Chow, Allisa Clemens, Claire B. Discenza,Jason C. Dugas,Chrissa Dwyer,Timothy Earr,Connie Ha, Yvonne S. Ho,David Huynh, Edwin I. Lozano, Srini Jayaraman,Wanda Kwan,Cathal Mahon,Michelle Pizzo,Yaneth Robles-Colmenares,Elysia Roche, Laura Sanders, Alexander Stergioulis,Raymond Tong,Hai Tran,Joy Yu Zuchero,Anthony A. Estrada,Kapil Gadkar, Christopher M. M. Koth,Pascal E. Sanchez,Robert G. Thorne,Ryan J. Watts,Thomas Sandmann,Lesley A. Kane,Frank Rigo,Mark S. Dennis,Joseph W. Lewcock,Sarah L. Devos

Science Translational Medicineno. 760 (2024)

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Phosphorylation of the Nuclear Poly(a) Binding Protein (PABPN1) During Mitosis Protects Mrna from Hyperadenylation and Maintains Transcriptome Dynamics

Jackson M. Gordon,David Phizicky,Leonard Schaerfen,Courtney L. Brown,Dahyana Arias Escayola,Jean Kanyo,TuKiet T. Lam,Matthew D. Simon,Karla M. Neugebauer

NUCLEIC ACIDS RESEARCHno. 16 (2024): 9886-9903

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Expanding and Improving Analyses of Nucleotide Recoding RNA-seq Experiments with the EZbakR Suite

Isaac W Vock, Justin W Mabin,Martin Machyna, Alexandra Zhang,J Robert Hogg,Matthew D Simon

bioRxiv the preprint server for biology (2024)

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E-box Independent Chromatin Recruitment Turns MYOD into a Transcriptional Repressor

Chiara Nicoletti,Jimmy Massenet,Andreas P Pintado-Urbanc, Leah J Connor, Monica Nicolau, Swetha Sundar, Mingzhi Xu,Anthony Schmitt, Wenxin Zhang, Zesen Fang, Tsz Ching Indigo Chan, Stephen J Tapscott, Tom H Cheung,Matthew D Simon,Luca Caputo, Pier Lorenzo Puri

bioRxiv the preprint server for biology (2024)

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Aquaporin-4 Mis-Localization Slows Glymphatic Clearance of Α-Synuclein and Promotes Α-Synuclein Pathology and Aggregate Propagation

Molly Braun,Matthew J Simon, Jay Jang, Keith Sanderson, Justyna Swierz,Mathew Sevao,Alexandra B Pincus,Allison J Schaser,Jonathan E Elliott,Miranda M Lim,Vivek K Unni,Abigail G Schindler,C Dirk Keene,Caitlin S Latimer,Jeffrey Iliff

bioRxiv the preprint server for biology (2024)

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论文共 137 篇作者统计合作学者相似作者