Dr. Shiels uses innovative approaches to confront high-impact public health questions with population-based data resources and descriptive analyses. She combines multiple population-based data resources, quantifies the contribution of risk factors to time trends, and disaggregates cancer incidence and mortality rates to reveal underlying patterns and explanatory mechanisms. Currently, her research program focuses on 1) quantifying cancer risk and burden in people with HIV, 2) estimating the impact of risk factors on changing cancer rates over time, and 3) providing insights into emerging public health crises in the United States.