My research focuses on improving our understanding of the cellular responses mediated by G Protein-Coupled Receptors (GPCRs) with particular focus on novel emerging paradigms that challenge the traditional views on GPCR signalling and regulation and promise to change the way drugs are screened and validated. Such two inter-related paradigms in GPCR biology are: GPCR positional dynamism (encompassing GPCR regulation and compartmentalised signalling) and GPCR conformational dynamism (namely allosterism and biased agonism). The general premise of my work is that a greater understanding of the mechanisms of action of GPCRs will lead to novel, more efficacious, GPCR-targeted therapeutics.