Michael Willem

The main focus of the group is on the Alzheimer`s disease associated beta-secretase (BACE1) and alpha-secretase (ADAM10). The generation of amyloid peptides (Abeta) from the amyloid precursor protein (APP) is initiated by BACE1, whereas subsequent gamma-secretase cleavage produces Abeta peptides. We focus on the identification of cellular mechanisms involved in the physiological and pathophysiological regulation of BACE1. Therefore we study the function of BACE1 in animal models and in AD.