While her research covers a wide range of substantive areas related to women’s health, she has focused primarily on pregnancy outcomes—with an emphasis on infertility and preterm birth. Recently, in collaboration with the Division of Gynecologic Oncology at BIDMC, Dr. Hacker has engaged in several research projects investigating the financial toxicity of gynecologic cancers, with an emphasis on ovarian cancer. Further, Dr. Hacker has a longstanding breast cancer collaboration with the Cancer Risk and Prevention Program at BIDMC. Dr. Hacker has served as principal investigator or co-investigator on multiple clinical and basic science research studies. She also serves as member of the institutional review board at BIDMC. Dr. Hacker devotes substantial effort to mentoring medical students, public health graduate students, residents, fellows and faculty to facilitate clinical research related to reproductive health. In addition, she has taught a variety of courses in epidemiology at the undergraduate and graduate level.