Darren J. Mitchell - Epinova Discovery Performance Unit and Molecular Discovery Research, GlaxoSmithKline

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Papers共 32 篇Author StatisticsCo-AuthorSimilar Experts

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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787

David J. Hirst,Paul Bamborough, Niam Al-Mahdi,Davina C. Angell,Heather A. Barnett,Andrew Baxter,Rino A. Bit,Jack A. Brown,Chun-wa Chung,Peter D. Craggs, Robert P. Davis,Emmanuel H. Demont,Alan Ferrie,Laurie J. Gordon, Isobel Harada, Tim C. T. Ho, Ian D. Holyer,Edward Hooper-Greenhill,Katherine L. Jones,Matthew J. Lindon,Cerys Lovatt,David Lugo,Claire Maller, Grant Mcgonagle,Cassie Messenger,Darren J. Mitchell, David D. Pascoe,Vipulkumar K. Patel,Christopher Patten,Darren L. Poole,Rishi R. Shah,Inmaculada Rioja,Kayleigh A. J. Stafford, Daniel Tape,Simon Taylor,Natalie H. Theodoulou,Laura Tomlinson,Ian D. Wall,Christopher R. Wellaway,Gemma White,Rab K. Prinjha,Philip G. Humphreys

JOURNAL OF MEDICINAL CHEMISTRYno. 12 (2024): 10464-10489

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Design and Characterization of 1,3-Dihydro-2h-benzo[d]azepin-2-ones As Rule-of-5 Compliant Bivalent BET Inhibitors

Paul Bamborough,Chun-wa Chung,Nicole C. C. Goodwin,Darren J. J. Mitchell, Christopher E. E. Neipp,Alex Phillipou,Alex Preston, Rab K. K. Prinjha,Peter E. E. Soden,Robert J. J. Watson,Emmanuel H. H. Demont

ACS MEDICINAL CHEMISTRY LETTERSno. 9 (2023): 1231-1236

Cited2Views0WOSBibtex

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression

Katherine L. Jones, Dominic M. Beaumont,Sharon G. Bernard,Rino A. Bit,Simon P. Campbell,Chun-wa Chung,Leanne Cutler,Emmanuel H. Demont, Kate Dennis,Laurie Gordon, James R. Gray,Michael Haase,Antonia J. Lewis,Scott McCleary,Darren J. Mitchell, Susanne M. Moore,Nigel Parr, Olivia J. Robb,Nicholas Smithers,Peter E. Soden,Colin J. Suckling,Simon Taylor,Ann L. Walker,Robert J. Watson,Rab K. Prinjha

Journal of Medicinal Chemistry（2021）

Cited25Views0WOSBibtex

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