Mitchell Gulkis - University of Florida

基本信息

浏览量：3

职业迁徙

个人简介

My research is focused on elucidating the key interactions between the downstream enzymes in the eukaryotic base excision repair (BER) pathway which ensure proper pathway coordination. I use a biochemical, biophysical, structural, and cellular techniques as a multi-disciplinary approach to address key questions underlying BER pathway coordination.

研究兴趣

论文共 15 篇作者统计合作学者相似作者

按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选

Uncovering Nick DNA Binding by LIG1 at the Single-Molecule Level

Surajit Chatterjee, Loïc Chaubet,Aafke van den Berg,Ann Mukhortava,Mitch Gulkis,Melike Çağlayan

bioRxiv the preprint server for biology (2024)

引用0浏览0WOS引用

Structures of LIG1 Provide a Mechanistic Basis for Understanding a Lack of Sugar Discrimination Against a Ribonucleotide at the 3'-End of Nick DNA

Kanal Elamparithi Balu,Mitchell Gulkis,Danah Almohdar,Melike Caglayan

JOURNAL OF BIOLOGICAL CHEMISTRYno. 5 (2024)

引用3浏览0WOS引用

Unfilled Gaps by Polβ Lead to Aberrant Ligation by LIG1 at the Downstream Steps of Base Excision Repair Pathway

Mitchell Gulkis,Ernesto Martinez,Danah Almohdar,Melike Caglayan

NUCLEIC ACIDS RESEARCHno. 7 (2024): 3810-3822

引用4浏览0WOS引用

Biochemical, Structural, and Single-Molecule Characterization of LIG1 Active Site Mutants Demonstrate Role of F635 and F872 Residues for Faithful Ligation

Mustafa Kalaycioğlu,Mitchell Gulkis, Kar Men Lee, Surajit Chatterjee, Kanal Balu,Qun Tang, Jacob E Ratcliffe, Erick Castro, Danah Almahdor,Melike Çağlayan

bioRxiv the preprint server for biology (2024)

引用0浏览0WOS引用

Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal Ph-Induced Changes