The main interest of my research has been towards gaining a greater understanding of the neural control of the kidney in terms of renal haemodynamic and excretory function. This has involved a careful analysis at the key regulatory role played by renal sympathetic nerves. The initial studies during my Master and PhD studies was to explore the functional contribution of alpha 1 adrenoceptor subtypes and angiotensin II receptors in pathophysiological states, with specific regard to hypertension, diabetes, heart failure, chronic and acute renal failure and diet-induced metabolic syndrome. This theme has continued in my postdoctoral work where studies are being extended to determine the interactions between the renin-angiotensin and nitric oxide systems in the brain to regulate the sympathetic