Mehta has designed and led several national and international clinical studies, receiving NIH and NCI grants and being awarded many honors. He has held national leadership positions in numerous organizations including the American Board of Radiology, the FDA Radiological Devices Panel, the American Society for Radiation Oncology, the American Society of Clinical Oncology, the Society of Neuro-Oncology, etc.

A well-respected clinician and researcher, Mehta has over a thousand publications, including medical journal manuscripts, book chapters, and professional abstracts, and serves on the editorial board of several peer-reviewed journals.