His research has focused upon multiple aspects of phospholipid biochemistry, molecular biology and genetics. A significant portion of his career has been dedicated to elucidating the mechanisms of inter-organelle phospholipid traffic and metabolism, using yeast genetics and molecular biology. Additional studies have focused upon elucidating the structural details of phospholipid-protein interactions, especially with the phospholipid constituents of pulmonary surfactant. Current topics being pursued in his laboratory include: 1) antagonism of innate immunity and respiratory viral infections by anionic phospholipids present in pulmonary surfactant, 2) application of lipids as inhibitors of viral infection and virus- induced exacerbations of chronic lung diseases, 3) development of high throughput screening strategies to target lipid metabolism in pathogens (bacteria, fungi and parasites) and neoplastic tissues for therapeutic purposes.