Osamu Takeuchi - Graduate School of Medicine, Kyoto University

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Overview of the research
Innate immunity is critical not only for early recognition of pathogens, but also for evoking inflammation in response to various stresses. I have been analyzing molecular mechanisms regulating inflammation by focusing on (1) cytokine regulation via mRNA stability, (2) Toll-like receptor (TLR) signal transduction mechanisms and (3) regulation of gene transcription downstream of TLR using mouse models.

Research Interests

Papers共 667 篇Author StatisticsCo-AuthorSimilar Experts

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A Feedback Amplifier Circuit with Notch and E2A Orchestrates T-cell Fate and Suppresses the Innate Lymphoid Cell Lineages During Thymic Ontogeny

Kazuko Miyazaki,Kenta Horie,Hitomi Watanabe,Reiko Hidaka, Rinako Hayashi, Norihito Hayatsu, Kentaro Fujiwara, Rei Kuwata,Takuya Uehata, Yotaro Ochi, Makoto Takenaka,Risa Karakida Kawaguchi,Koichi Ikuta,Osamu Takeuchi,Seishi Ogawa,Katsuto Hozumi,Georg A Holländer,Gen Kondoh,Taishin Akiyama, Masaki Miyazaki

Genes & developmentno. 5-6 (2025): 384-400

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NEDD4-binding Protein 1 Suppresses Hepatitis B Virus Replication by Regulating Viral RNAs

Nobuhiro Kobayashi,Saori Suzuki, Yuki Sakamoto,Rigel Suzuki, Kento Mori, Yume Kosugi,Tomoya Saito, Yuan Ma, Lihan Liang, Takuma Izumi,Kisho Noda,Daisuke Okuzaki,Yumi Kanegae, Sanae Hayashi,Yasuhito Tanaka,Atsuya Yamashita,Kohji Moriishi,Yoshiharu Matsuura,Osamu Takeuchi,Tomokazu Tamura,Akinobu Taketomi,Takasuke Fukuhara

The Journal of general virologyno. 3 (2025)

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Characteristic Gene Expression Profile of Intestinal Mucosa Early in Life Promotes Bacterial Colonization Leading to Healthy Development of the Intestinal Environment

Yuu Nishinarita,Jun Miyoshi, Satoshi Kuronuma,Haruka Wada, Noriaki Oguri, Noritaka Hibi,Osamu Takeuchi,Yoshihiro Akimoto,Sonny T M Lee,Minoru Matsuura,Taku Kobayashi,Toshifumi Hibi,Tadakazu Hisamatsu

Scientific reportsno. 1 (2025): 18437-18437

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Epithelial Regnase-1 Inhibits Colorectal Tumor Growth by Regulating IL-17 Signaling Via Degradation of NFKBIZ Mrna

Eriko Iguchi,Atsushi Takai, Natsumi Oe, Yosuke Fujii, Mayuki Omatsu,Haruhiko Takeda,Takahiro Shimizu, Takahisa Maruno,Yuki Nakanishi,Masanori Yoshinaga,Takashi Maruyama,Hiroyuki Marusawa,Kazutaka Obama,Osamu Takeuchi,Hiroshi Seno

Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2025): e2500820122-e2500820122

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Time-resolved Force Microscopy Using the Delay-Time Modulation Method

Hiroyuki Mogi, Rin Wakabayashi,Shoji Yoshida,Yusuke Arashida,Atsushi Taninaka,Katsuya Iwaya, Takeshi Miura,Osamu Takeuchi,Hidemi Shigekawa

APPLIED PHYSICS EXPRESSno. 1 (2024)

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Measurement of the Intracellular Active Metabolites of Thiopurine Drugs to Evaluate the Enzymatic Activity of Nudix Hydrolase 15 in Human Blood Samples

Hitomi Okamoto,Yoichi Tanaka,Yoshio Shibagaki,Satoshi Kuronuma,Yusuke Miyatani,Satoko Umeda,Emi Mishiro-Sato,Osamu Takeuchi,Seisuke Hattori,Taku Kobayashi,Mitsuru Okuwaki

Journal of Chromatography B（2024）

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Levels of Environmental Contamination with SARS-CoV-2 in Hospital Rooms and Salivary Viral Loads of Patients with Coronavirus Disease 2019

Hidehito Matsui,Yusuke Suzuki,Sohei Nakayama,Takanori Asakura,Osamu Takeuchi, Kaori Kusatsugu,Chihiro Ueda,Eri Nakajima,Yumiko Suzuki,Harumi Endo,Miho Sugamata,Yukiko Takarabe,Yukie Yamaguchi, Kazuhito Horie,Yoshikazu Kobayashi,Satoshi Kuronuma,Yasuo Imoto,Hideaki Hanaki

JOURNAL OF INFECTION AND CHEMOTHERAPYno. 4 (2024): 315-322

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PLK1 Overexpression Suppresses Homologous Recombination and Confers Cellular Sensitivity to PARP Inhibition

Sookhee Pae,Anna S. Sedukhina, Runa Sugiyama, Sarah J. Atanacio,Tatsuru Ohara, Masato Ishii,Kimino Minagawa, Romaan Akichjev, Fumie Go, Zayan Chandankeri, Zoran M. M. Janjetic,Eri Sato, Ayako Yamaura, Rei Meguro, Kishore Palanisamy,Ichiro Maeda,Osamu Takeuchi,Nao Suzuki,Kazuo Yudo,Juan A. Bernal,Ko Sato

SCIENTIFIC REPORTSno. 1 (2024)

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TAK1-binding Protein 2 (TAB2) and TAB3 Are Redundantly Required for TLR-induced Cytokine Production in Macrophages

Tanveer Ali,Huong Minh Nguyen, Naeem Abbas,Osamu Takeuchi,Shizuo Akira,Toshihiko Suzuki,Goro Matsuzaki,Giichi Takaesu

INTERNATIONAL IMMUNOLOGYno. 9 (2024): 439-450

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Osamu Takeuchi(竹内理)

Professor

Papers共 667 篇Author StatisticsCo-AuthorSimilar Experts