We are pursuing several lines of research: the characterization of mutations in type I collagen genes that give rise to forms of osteogenesis imperfecta and other disorders, the identification and characterization of mutations in type III collagen genes which give rise to Ehlers-Danlos syndrome type IV, identification of proteins in the intracellular and extracellular processing pathways that identify abnormal collagen proteins, the mechanisms of mRNA processing in collagen genes,the dispersion of repetitive elements within the COL3Al gene of type III collagen, and mutations in the type V collagen genes which give rise to milder forms of EDS.