Her research interests are in studying the structure-to-function relationship of membrane proteins involved in bioenergy conversion and infectious diseases. She was an integral part of a team of ASU researchers and international colleagues that developed the technique of serial femtosecond nanocrystallography for analyzing proteins using high-intensity X-ray Free Electron Lasers (XFEL). Professor Fromme has vast experience unravelling the structure and function of photosystem I and II proteins and ATP synthase, which are each crucial for solar energy conversion in our biosphere. Professor Fromme has published over 200 articles and is internationally recognized as a leader in photosynthesis, protein macromolecular crystallography using synchrotrons and protein nanocrystallography using XFELs.