Research is in the broad area of signal transduction with a particular focus on type-2 diabetes and cancer. The lab encourages a collaborative approach with research groups across New Zealand and overseas to make the most of our research programmes. The main research current areas are (i) identifying new combinations of old drugs targeting signal transduction pathways to get improved efficacy in treating cancer, (ii) developing new drugs aimed at improving the efficacy of immunotherapies for cancer (iii) investigating mechanisms controlling the secretion of insulin from ß-cells and (iv) understanding how genetic factors can be used to improve prevention and treatment strategies for metabolic diseases such as type-2 diabetes in Māori and Pacific peoples.