I am first and co-author of more than 250 peer reviewed publications and several book chapters (Scopus H-index 63) and am active in different national and international societies (eg ESMO, AACR, VVOG, EUSOMA). I was the first author of two recent papers of the EUSOMA task force on the effect of EUSOMA accreditation on the quality of breast cancer care in Europe. I was co-author of several multicentre international clinical trials on hormonal treatment of breast cancer. My present research interests are the effects of neoadjuvant treatment on the microenvironment in breast cancer, circulating tumour cells and cell free DNA in breast cancer patients and the biology and i mmune typing of inflammatory breast and cervical cancer. I am heavily involved in improving the quality of multidisciplinary breast cancer care in his hospital and Belgium and have published several papers and book chapters on this subject. I am a member of the editorial board of the European Journal of Surgical Oncology, and the International Journal of Molecular Sciences and am regularly asked to review papers for many other journals. As a member of the executive board of the European Society of Breast Cancer Specialists (EUSOMA) since 2020 I am heavily involved in the prevention, treatment of breast cancer on a European level , in close relation with policy makers. As I have more the 35 year experience in translational and clinical research in breast and gynaecological cancers, I feel I can contribute is the submitted project on several levels.