Research Interests
Biomarkers and heterogeneity in ALS
One of the challenges of ALS is understanding disease heterogeneity. Our work studies the variability of patients by detailed clinical, laboratory and genetic studies, and by identifying biomarkers that are associated with disease. We use a range of techniques including neurophysiology, MRI, metabolic studies, genetic studies, immune markers and biochemical studies including proteomics. We are using this information to analyse whether patients can be assigned into subgroups and to correlated with survival.
Inflammatory neuropathy studies
This is an ongoing study of the immunological basis and genetic basis of acute and chronic inflammatory neuropathy
Pregnancy and MS
This study is exploring the short and long term effects of pregnancy in multiple sclerosis. This includes the clinical effects of pregnancy and the effects on gene expression and methylation
Immunology of stroke
This study involves documenting the immune responses after human stroke and determining the significance of these responses.
Neuromuscular disease
This work is based at the Neuromuscular clinic at Royal Brisbane and Women's Hospital, and involves correlation of genotype and phenotype of inherited neuromuscular disease