An internationally renowned human physiologist in the area of human energy and muscle metabolism. Made key contributions to the study of the relation between mitochondrial function and ectopic fat storage in muscle and type 2 diabetes/insulin resistance. Ample experience with human experimental intervention studies, clinical phase 2 trials and lifestyle interventions. Experience with leading several large collaborative research consortia. Founder and member of the EASD exercise and physical activity study group and one of the foundesr of the Annual Dutch Translational Metabolism Conference. Chair of the EASD early career academy. Frequent speaker at international conferences.