As well as establishing and successfully leading drug discovery project groups yielding clinical candidates, Professor Workman’s personal and collaborative research utilises molecular pharmacology and chemical biology approaches, including high-throughput and genome-wide as well as hypothesis-driven strategies, to interrogate cancer biology, identify and validate new drug targets, discover and develop chemical tools and drugs acting on these targets, identify predictive and mechanism of action biomarkers, and elucidate mechanisms of drug sensitivity of resistance.
He is especially interested in exploiting the addictions, vulnerabilities and dependencies of cancer cells using a combination of small molecule tools and drugs alongside molecular genetic techniques.