Pierre Khoueiry

Regulatory regions bind transcription factors and active or repress their target genes. The main focus of my group is to understand principles of transcriptional regulation in development and disease in general including cancer, diabetes, neurodegenerative and rare diseases. Mainly, we study the dynamics of regulatory regions activity to get insights into the mechanisms that lead to developmental defects and disease progression. We combine computational (Bioinformatics) and experimental approaches, to contrast information between healthy and disease states. We use evolutionary information (comparative genomics) to gain better insights on functional regulatory elements.