Ralf Bartenschlager is a virologist working in the field of molecular virology of Flaviviridae. His research focuses on the viruses belonging to the family Flaviviridae. Primary topics are the Dengue virus, the most prevalent virus worldwide that is transmitted by mosquitos, and the hepatitis C virus, which is a main causative agent of acute and chronic liver diseases.
Ralf Bartenschlager is best known for his major contributions to the exploration of the replication cycle of these two viruses. One of the most important contributions was the establishment of the first robust cell culture system for the hepatitis C virus. This achievement laid the ground for the identification of the direct acting antivirals that have become available for treatment of chronic hepatitis C.
In addition, Ralf Bartenschlager has expanded his research activities towards host – pathogen interactions. A special focus is the analysis of the complex interplay between hepatitis C virus and Dengue virus with the innate and adaptive immune response. These analyses are based primarily on innovative imaging-based methods and systems biology, including mathematical modeling, with the aim to decipher the complex interactions between the host and its pathogens.