Dr. Shave is known for his work examining the acute and chronic effects of exercise and/or environmental stress upon the heart. Using echocardiography and biomarkers Dr. Shave and his colleagues have provided insight to the beneficial and potentially negative effects of endurance exercise upon the heart, the influence of exercise on cardiac remodeling and the ventricular mechanics that underpin cardiac function in health and disease. Recently, Dr. Shave established the International Primate Heart Project to examine heart disease in great apes and to provide insight into the evolution of the human heart. Dr. Shave’s work will continue to combine comparative and experimental physiology approaches to further understand structural and functional cardiovascular adaptations to exercise in a range of populations with a specific focus on human evolution and the potential of cardiovascular mismatch disease.