His current research focuses on elucidating the cellular and molecular mechanisms whereby apoE4 results in neurodegenerative disorders, and on approaches for altering the detrimental effects of apoE4 in neurons. He has identified a series of small molecules that convert the abnormal structure of apoE4 to a much less toxic structure. In addition, his lab is focusing on how apoE4 expression in neurons impairs cellular metabolism and mitochondrial function.