His research interests have always been in a creative application of Systems Engineering concepts and principles to molecular and submolecular level fundamental biological problems that have proved resistant to solution for several decades. He has repeatedly been forced to evolve his own, original approaches that solve these problems with style. Among such problems are how the universal biological currency, adenosine triphosphate (ATP) is synthesized, and how muscle generates contractile force using the synthesized ATP. Since the synthesis and utilization of ATP is the most prevalent chemical reaction in our body that is used for the function of brain, nerve, muscle, liver and other tissues, this is a very important scientific problem. However, despite a colossal amount of research during the last 75 years, the detailed molecular mechanism of ATP synthesis has remained an enigma. By use of innovative systems approaches, he has proposed a novel, unified molecular mechanism now called Nath’s Torsional Mechanism of Energy Transduction and ATP Synthesis and Nath's Two-ion Theory of Energy Coupling.