His main research interests include bioeffect modeling; biomathematics; applied biostatistics; clinical trial design; evidence-based medicine; late effects of radiotherapy; clinical radiobiology; integration of data from genomics, proteomics, and molecular imaging into novel therapeutic strategies.

In addition to his role as Director of the Biostatistics Shared Service, Dr. Bentzen is a member of the Experimental Therapeutics Program within the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Program in Oncology. He collaborates with both basic and clinical researchers, aiming for the rapid translation of discoveries from the laboratory to the clinic. Dr. Bentzen’s research focuses on three broad fields: normal-tissue radiation biology; biomarkers, including genomic and imaging biomarkers, in predictive oncology; and the pre-clinical and clinical development of drug-radiation combinations.