In 1999, he was awarded an FRCS from the Royal College of Surgeons in Edinburgh, Scotland, and in 2000 he was awarded an FRCS ad eundum from the Royal College of Surgeons in England. In 2008, the German Surgical Society elected him as an honorary fellow. In 2008, he received an FRCS by unanimous election of the Council of the Royal College of Surgeons of England, the highest distinction conferred by the Council, and was inducted as an honorary member of the Association of Coloproctology of Great Britain and Ireland. In 2011, he was elected as an honorary lifetime fellow of the Colorectal Society of Australia and New Zealand. In 2012, Dr. Wexner was awarded the degree of PhD honoris causa by the University of Belgrade. In 2015, he was awarded honorary membership in the European Surgical Association and also in the European Society of Coloproctology. In 2016, Dr. Wexner was recognized by Cleveland Clinic Florida as a Master Clinician. In 2017, Dr. Wexner was awarded, honorary fellowship in the Royal College of Surgeons in Ireland. In 2019, Dr. Wexner was inducted as a member of the Academy of Master Surgeon Educators and was awarded an honorary fellowship by the Royal College of Physicians and Surgeons of Glasgow, Scotland. In 2022, he received an honorary fellowship from the Royal College of Surgeons of England.