Skills and Expertise
Active Immunotherapy
Cancer Immunology
Tumor Immunology
Cancer Diagnostics

The Shukla lab is a highly translational group focused on antigen discovery and development of personalized immunotherapies. We develop computational approaches and harness state-of-the-art bulk and single-cell sequencing technologies and experimental assays to identify the full complement of tumor antigens in patient samples, and their cognate T-cell receptors. We are creating the next generation of personalized cancer vaccines designed to target antigens identified within each patient. These novel vaccination approaches will be tested in clinical trials across multiple tumor types.

We are building pipelines and machine learning models for integrated multi-omic analysis in order to elucidate mechanisms governing immunogenicity, immune escape and clinical outcomes to cancer immunotherapy. We are also establishing a comprehensive computational toolkit for characterization of highly polymorphic immune system-related genes which will significantly enable fundamental and translational research in tumor immunology.