As a Musculoskeletal Radiologist, I try to identify the cause of one's pain, discomfort, inflammation or other related musculoskeletal symptom(s) using clinical imaging approaches such as magnetic resonance imaging (MRI), computed tomography, digital radiography & ultrasound. However, these current approaches have limitations in accurately identify pain generators. Accordingly, my group along with my collaborators have been developing clinical imaging methods that would objectively pinpoint the site of pain generation using novel agents that specifically seek out molecular and cellular pain markers to highlight hypersensitive pain-sensing nerves. Successful validation of this approach will aid in the diagnosis of pain generators but also facilitate more intelligent management of chronic pain, minimize unnecessary surgeries, improve outcomes, aid in the development of novel analgesics and potentially reduce healthcare costs associated with the management of chronic pain.