The main research focus of my group is identifying the role of dysfunctional energy generation in neurodegenerative conditions In vitro we use various cell models, including primary patient cells and genetically reprogrammed human progenitor cells and in vivo we use models such as zebrafish to investigate the role of astrocyte and neurone energy metabolism and how they affect disease progression. We are interested in; How MND effects metabolic pathway regulation and interaction. How metabolism responds to disease specific cellular stress such as oxidative stress and hypoxia. How the disease affects the metabolic response to ageing in patients.