New neurons are continuously generated in the adult brain. Some fundamental questions on adult neurogenesis remain largely unknown. Therefore, a better understanding of the developmental processes for new neurons is of great importance. These studies will also establish a window through which we can see the ‘developmental processes’ in the adult neural circuits. Furthermore, the results may pave the way for cell-replacement therapy although there is still a long way to go.

The goal of my lab is to examine the generation, integration and function of new neurons. We use molecular, cellular, in vitro / in vivo imaging, physiological and behavioral approaches to study where, when and how these new neurons integrate into the existing adult circuitry. Other than the mechanisms of integration, understanding the physiological function of these integrating/integrated neurons in the brain is another goal of the lab.