His research is focussed on acute therapy for both ischemic stroke and intracerebral hemorrhage, particularly the use of advanced imaging in selection of therapy. He is a consulting editor for Stroke and serves on editorial boards of the International Journal of Stroke, the European Stroke Journal and the Journal of Clinical Neuroscience.

He leads a large clinical stroke research group at the Royal Melbourne Hospital/University of Melbourne, working in close collaboration with Geoffrey Donnan, Professor of Neurology, University of Melbourne. He is the Co-Lead (with G Donnan) of the MRFF Frontiers grant on Prehospital Stroke Care (2021-2025) and is the CIA on a Stroke Program Grant (2017-2021) which was awarded by NHMRC as the top program grant in Australia (2015), his fourth successive NHMRC stroke program grant. He was CIA of an NHMRC CRE grant for Translational Neuroscience (2011-2015), with continuous NHMRC support for >30 years. He has published more than 550 peer-reviewed papers (h-Index 101, Scopus), 3 books and >45 book chapters. Stroke research at the MBC at RMH and the University of Melbourne is internationally renowned and has provided outcomes that have directly linked to advances in therapy and changes in clinical practice.