RESEARCH INTERESTS
The design and synthesis of drug prototypes, total synthesis of medicinally important natural products, asymmetric synthesis, supramolecular assembly, peptidomimetics, glycomimetics, morphinomimetics, amino acids, carbohydrates, ligand design for catalysis and methodology, aspects of chemical biology and chemoproteomics.
Current projects:
New methodologies in chemical proteomics to study the interaction of synthetic cytotoxic sphingolipids with target proteins.
Ways to potentiate antisense oligonucleotide activity and delivery.
Synthesis of constrained azacycles to probe CNS receptor interactions.
Peptido- and glycomimetics to validate revelant enzyme active site interactions.
Total synthesis and study of pharmacophoric elements of lignan, quinolone, and Daphniphyllum alkaloid bioactive natural products as anticancer, antiparasitic, antibiotic, and antifeedant agents.
Reagent and catalyst design for asymmetric synthesis.