An unsupervised network analysis showed that over-expression of digenomic proteins in hybrids is associated with elevated levels of proteostasis elements including chloroplast chaperones and protein complex assembly factors. We are exploring whether these proteostasis elements cause the increased levels of digenomic protein complexes. In contrast, inbreds display elevated levels of ERAD and UPR indicating they are experiencing proteostasis stress. Our focus, therefore, is on the relationship between proteostasis and heterosis.