The focus of Dr. Miller's research career has been on improving the clinical care of newborns at high-risk of brain injury including newborns with congenital heart disease and those born preterm. The use of advanced brain imaging offers tremendous potential to understand the mechanisms and timing of brain injury in high-risk newborns and fetuses. Findings from his research program will ultimately inform the design and implementation of new strategies to promote optimal brain development and neurodevelopmental outcome. Dr. Miller uses multimodal magnetic resonance brain imaging (e.g. MRI, diffusion tensor imaging spectroscopic imaging) to study clinical factors associated with brain injury and neurodevelopmental outcomes among various fetal and neonatal populations (fetuses & newborns with congenital heart disease; babies born preterm). He is actively involved with numerous prospective, longitudinal studies including those with colleagues in Canada and internationally.