Areas of current methodological research interests include: 1) methods in clinical trials including survival analysis, Bayesian clinical trials design, and the use of Markov processes in modeling clinical data; 2) modern regression techniques especially nonparametric regression and regularization methods; and 3) general methodology in longitudinal data analysis.

I am also involved in several large scale collaborative projects. I was the primary statistician for many breast cancer treatment protocols for the National Surgical Adjuvant Breast and Bowel Project (NSABP) . More than 15,000 patients were followed across these trials. I am now an Associate Director of the Division of Biostatistics and Science for the newly formed cancer cooperative group, NRG Oncology. In addition to my involvement in cancer research, Until recently, I had been a co-director of the Research Design and Biostatistics Unit for the ACISR, a large center for prevention of adult late-life depression, headed by Dr. Charles Reynolds in the Department of Psychiatry in the University of Pittsburgh School of Medicine. In this capacity, I oversaw the design, analysis and development of methodology for three prospective randomized studies that compare strategies for preventing depression in older adults. Currently, I am involved with a group that investigates the aging brain with respect to amyloid deposits and other features of brain scans. Some of this work involves developing statistical methodology to distinguish a small number of important features in brain imagining datasets that often consist of extremely large numbers of features that potentially could be related to aging.