During the first 20 years of his scientific pursuits, Dr. Paus worked on functional and structural organization of the human cerebral cortex using a variety of approaches including studies of patients with brain lesions, functional and structural neuroimaging, and brain stimulation.

In the last 15+ years, his work integrates epidemiology, neuroscience and genetics – through a new discipline of population neuroscience - in the pursuit of knowledge relevant for child and youth brain health. This research draws on data acquired in a number of cohorts based in North and South America and Europe.