We will study epigenetic diseases, investigate causality of the relationship between the epigenetic code and diseases, perform epigenetic drug screenings for therapeutic applications, and validate the efficacy and toxicity of the drug. We will initiate new challenging projects to identify novel epigenetic code and regulators and determine their in vivo functions using mouse models. The results will be integrated at the epigenomic, transcriptomic, and proteomic level. Big data and deep-learning will be applied for multidisciplinary research.