Being a previous Cardiologist, my research interest is in the molecular basis of cardiovascular diseases, focusing on genetic small vessel diseases (SVD) and the functions of the causative genes such as NOTCH3, in cardiovascular system. We utilise patient-specific induced pluripotent stem cells (iPSCs) as model system to study a range of genetic SVD in order to understand molecular mechanisms of the conditions, and identify biomarkers and therapeutic targets that could be generalised to the more common and sporadic form of SVD. We are particularly interested in understanding how cerebral vascular pathologies lead to the neurodegeneration and vascular dementia by interrogating interactions between different iPSC-derived vascular and neuronal cell types that form the neurovascular unit (NVU) in the brain. Other research interests of my group include nano-medicine/nano-targeting and avascular engineering.