Tim is known for his research in colorectal cancer, mainly as a clinical trial leader. He led four UK national MRC studies (CRO6, COIN, FOCUS3 and FOCUS4) and has published extensive papers both reporting the clinical findings and translational research studies from these trials. He also led the MRC stratified medicine consortium in colorectal cancer (S:CORT) including 7 UK universities in collaborative research. This has generated a rich dataset of 2000 colorectal cancer patients including anonymised clinical data, genomic transcriptomic and methylation data all linked to digitised image of the H&E slide.