We focus on the prevention and treatment of oral diseases and are roughly divided into four themes. 1. Betel nut induces abnormal gene expression of oral cancer. 2. Analysis of the characteristics and biocompatibility of dental materials. 3. Natural products are used to prevent oral cancer, oral pathogens, xerostomia, and oral mucositis. 4. Improve the efficacy of photodynamic therapy under hypoxic conditions.