The DDL team consists of accomplished scientists and skilled technicians from multiple scientific disciplines who have joined the lab to find effective, safe therapeutics for the treatment of neurodegenerative disease, with a focus on Alzheimer's disease. Led by Varghese John, Ph.D, the team works together to conduct most aspects of preclinical drug discovery, from development of phenotypic screens and target validation, to medicinal chemistry for hit-to-lead optimization, in vitro ADME-T studies for lead advancement, in vivo pharmacokinetic and pharmacodynamic testing for target engagement, and lead confirmation.