The main focus of Dr. Marconi’s research is to identify the biological, social and behavioral conditions which lead to disparities in HIV treatment response for domestic and international populations. Results from these studies inform the design of interventional trials with the goal to improve the quality of life for individuals living with HIV.

His domestic research activities have two primary components: (1) elucidating the role of inflammation in age-related diseases and HIV cure/eradication and (2) improving adherence and clinic retention for patients on ART. These studies have provided critical insights into the mechanisms driving virologic control and immunologic stability for Elite Controllers as well as HIV reservoir size and CD4 recovery for individuals receiving antiretroviral therapy (ART). Additional studies have identified key drivers of cardiovascular, metabolic, and renal disease. Ongoing clinical trials have been exploring ART simplification, Jak-STAT inhibition and other immune-based therapies. Research aimed at improving ART adherence and retention in care have included assessing the cost-effectiveness of ART in a free-access healthcare setting and examining the role of various behavioral interventions including a comprehensive, palliative care model, financial incentives, tablet-based technology, telehealth and cognitive-based meditation.